MEDICINES WITH ANTIOXIDANT TYPE OF ACTION IN COMPLEX THERAPY OF HEMODIALYSIS PATIENTS
(OVERVIEW) 

Barsuk Aleksandr L'vovich, Candidate of medical sciences, associate professor, sub-department of general and clinical pharmacology, Volga Research Medical University (10/1 Minina i Pozharskogo square, Nizhny Novgorod, Russia), E-mail: bar-suk@yandex.ru
Lovtsova Lyubov' Valer'evna, Doctor of medical sciences, associate professor, head of sub-department of general and clinical pharmacology, Volga Research Medical University (10/1 Minina i Pozharskogo square, Nizhny Novgorod, Russia), E-mail: lovcovalubov@mail.ru
Monakhov Andrey Anatol'evich, Candidate of medical sciences, associate professor, sub-department of general and clinical pharmacology, Volga Research Medical University (10/1 Minina i Pozharskogo square, Nizhny Novgorod, Russia), E-mail: and.monahov2017@yandex.ru 

615.272+616.6 

10.21685/2072-3032-2018-3-14 

Chronic hemodialysis is the main method of replacement therapy in patients with terminal stage of chronic renal failure. Cardiovascular pathology is one of the main causes of death of hemodialysis patients. Oxidative stress leads to endothelial dysfunction and it is significant in the pathogenesis of cardiovascular pathology in this category of patients. Theoretically, the use of drugs with antioxidant type of action can reduce the risk of cardiovascular complications in hemodialysis patients. Modern investigations show inconsistent results of the effect of ascorbic acid on oxidative stress, endothelial function, lipid profile in this category of patients. It should be noted that there is no generally accepted approach to dosing, routes of administration, duration of application of ascorbic acid in relation to the procedure of hemodialysis. 

chronic hemodialysis, oxidative stress, endothelial dysfunction, antioxidants, ascorbic acid 

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